Every reproductive endocrinologist knows that ovulation is triggered by estradiol. In our textbooks, the sequence is clear: Estradiol rises, triggers an LH surge, and ovulation follows, culminating in the formation of a corpus luteum, which produces progesterone to support implantation and pregnancy. It is straightforward and reassuringly precise, and it forms the backbone of our
The Dozortsev-Diamond paradigm: Is progesterone the true ovulation trigger? originally appeared in KevinMD.com.
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